Past Podcast Episodes

Welcome to a RealTalk MS special series on MS clinical trials. This special series is made possible through a generous grant from Sanofi.

In this final episode of this series, you'll meet Jan Janisch-Hanzlik. Jan lives with MS and is a participant in one of the clinical trials evaluating the safety and efficacy of CAR-T cell therapy for MS.

In CAR-T cell therapy, blood is taken from the patient or a healthy donor, much as you would donate blood. This blood is sent to a lab, where the white blood cells, or T-cells, are separated out and reprogrammed to carry a receptor designed to fight a particular condition. This receptor is known as a chimeric antigen receptor, or CAR.

Over several weeks in the lab, these fortified T-cells multiply until there are millions of them, then they're reintroduced to the patient by intravenous infusion. CAR-T cell therapy is already used to treat some blood cancers, and Jan is the first person in the world to receive this one-and-done treatment to treat MS. She's joining us to share her experience participating in the clinical trial and to give us an update on how she's doing following her treatment.

This special episode of RealTalk MS is made possible by a generous grant from Sanofi. Sanofi has two ongoing Phase 3 clinical trials in MS studying Frexalimab, an investigational second-generation anti-CD40 ligand monoclonal antibody. If you are interested in learning more about these clinical trials, please visit SanofiStudies.com

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I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!

Email: jon@realtalkms.com
Phone: (310) 526-2283

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At the age of 14, Michaela Janssen Pohl became a caregiver for her mother, who lives with MS.

I think most of us can agree that just being a teenager carries with it more than enough challenges. Those adolescent years are the years when just about everything in life starts changing. Imagine adding the responsibilities of being a caregiver to all the other things going on in a 14-year-old girl's life. Michaela joins me this week to explain how she found ways to survive and thrive in what can only be described as a challenging situation for any teenager.

We'll also explain why you might want to think a little differently about Giving Tuesday this year.

We're sharing all the details about the Phase 2 clinical trial focusing on Moderna's investigational Epstein-Barr vaccine and MS (and we'll explain why that might turn out to be important!)

We're talking about how MS impacts women's health issues with this year's winner of the Rachel Horne Prize for Women's Research in Multiple Sclerosis, Dr. Kristen Krysko.

And we're sharing the results of the Phase 2 clinical trial for PIPE-307, an investigational remyelination therapy.

We have a lot to talk about! Are you ready for RealTalk MS??!

Today: It's Giving Tuesday (and why that matters more this year than ever before)  :22

This Week: Becoming a caregiver for a parent with MS when you're 14 years old  3:27

A clinical trial focused on an EBV vaccine and MS is recruiting participants  4:25

Dr. Kristen Krysko discusses MS and women's health issues  7:52

Results from the Phase 2 clinical trial for PIPE-307 remyelination therapy  13:48

Michaela Janssen Pohl shares her story of becoming a caregiver at the age of 14  16:55

Share this episode  33:20

Next week's episode  33:40

SHARE THIS EPISODE OF REALTALK MS

Just copy this link & paste it into your text or email: https://realtalkms.com/431

ADD YOUR VOICE TO THE CONVERSATION

I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!

Email: jon@realtalkms.com
Phone: (310) 526-2283

And don't forget to join us in the RealTalk MS Facebook group!

LINKS

If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

DONATE: The National MS Society
https://nationalmssociety.org/donate

SIGN UP: Become an MS Activist
https://nationalmssociety.org/advocacy

PARTICIPATE: Phase 2 Clinical Trial for Moderna's EBV Vaccine and MS
https://clinicaltrials.gov/study/NCT06735248
Email: WeCareClinicalTrials@modernatx.com

JOIN: The RealTalk MS Facebook Group
https://facebook.com/groups/realtalkms

REVIEW: Give RealTalk MS a rating and review
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Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.

RealTalk MS Episode 431
Guests: Dr. Kristen Krysko, Michaela Janssen Pohl