May 30th is World MS Day! This year, the theme for World MS Day is “My MS Diagnosis,” and I've been thinking about what happens right after that diagnosis. After an individual hears, “You have MS.”
This week, Dr. Nancy Sicotte joins me to discuss the things you should know, the things you should be thinking about, and the things you should be doing in the first 100 days following an MS diagnosis.

Dr. Sicotte is the Chair of Neurology and Director of Multiple Sclerosis and Neuroimmunology at Cedars-Sinai in Los Angeles, and she's the past Chair of the National MS Society's National Medical Advisory Committee.
We're also sharing results of a study that showed an exercise hormone protected neurons from inflammatory attack in a mouse model of MS.
And we're sharing encouraging news about an experimental nasal spray that's been shown to delay disability progression and improve fatigue among people with non-active secondary progressive MS.
We have a lot to talk about! Are you ready for RealTalk MS??!
This Week: World MS Day! :22
Study reveals an exercise hormone has neuroprotective effects on a mouse model of MS 2:40
Tiziana shares evidence that Foralumab delays progression and improves fatigue in people with non-active secondary progressive MS 4:34
Dr. Nancy Sicotte looks at the first 100 days following an MS diagnosis 8:40
Share this episode 28:51
Next week 29:12
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LINKS
If your podcast app doesn't allow you to click on these links, you'll find them in the show notes at www.RealTalkMS.com
World MS Day Poster Maker
https://worldmsday.org/poster-maker
STUDY RESULTS: The Exercise Hormone Irisin Has Neuroprotective Effects in a Mouse Model of Multiple Sclerosis
https://www.nature.com/articles/s42255-026-01527-7
CLINICAL TRIAL: A Study of Nasal Foralumab in Non-Active Secondary Progressive Multiple Sclerosis Patients
https://clinicaltrials.gov/study/NCT06292923
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RealTalk MS Episode 456
Guest: Dr. Nancy Sicotte


