Myelin repair is a natural function. But, for people living with MS, that ability to repair myelin eventually stops working. New research led by my guest, Dr. Larry Sherman, may explain why that happens and point to new possibilities for future myelin repair treatments.

Dr. Sherman is a professor at the Oregon National Primate Research Center at Oregon Health & Science University, and his research focuses on how the brain and spinal cord respond to injury and disease, particularly in demyelinating conditions such as multiple sclerosis.
We're also sharing some potentially good news for people living with non-relapsing secondary progressive MS in Europe, but not in the United States.
We'll give you the details about an experimental drug that's just been submitted to the FDA and EMA for approval for treating relapsing forms of MS and primary progressive MS.
We'll share the results of a study that focused on the impact of a cancer diagnosis on MS care.
We'll tell you how Fernando Mendoza celebrated being named the #1 pick in this year's NFL draft.
And we're sharing news about a new AI tool for your doctor.
We have a lot to talk about! Are you ready for RealTalk MS??!
This Week: Why myelin repair stops working for people living with MS :22
EMA's Committee for Medicinal Products for Human Use recommends approval of Tolebrutinib 1:35
Roche submits Fenebrutinib for FDA and EMA approval 4:45
Study results show the effect of a cancer diagnosis on MS care 6:13
The first pick in the 2026 NFL draft, Fernando Mendoza, partners with the National MS Society to launch the Mendoza Family Fund 9:43
OpenAI launches ChatGPT for Clinicians 10:56
Dr. Larry Sherman discusses why myelin repair stops working for people with MS, and how his team may have found a way to restart it 14:37
Share this episode 27:59
Next week 28:19
SHARE THIS EPISODE OF REALTALK MS
Just copy this link & paste it into your text or email: https://realtalkms.com/452
ADD YOUR VOICE TO THE CONVERSATION
I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!
Email: jon@realtalkms.com
Phone: (310) 526-2283
And don't forget to join us in the RealTalk MS Facebook group!
LINKS
If your podcast app doesn't allow you to click on these links, you'll find them in the show notes at www.RealTalkMS.com
LISTEN: RealTalk MS Episode 440: An MS Specialist Responds to the FDA with Dr. William Conte
https://realtalkms.com/440
STUDY: Impact of Cancer on Multiple Sclerosis-Related Healthcare and Disease-Modifying Drug Use: A Multinational Cohort Study
https://journals.sagepub.com/doi/10.1177/13524585261437966
STUDY (Plain English Version): Impact of Cancer on Multiple Sclerosis-Related Healthcare and Disease-Modifying Drug Use: A Multinational Cohort Study
https://tremlettsmsresearchexplained.wordpress.com/2026/04/23/impact-of-cancer-on-multiple-sclerosis-related-healthcare-and-disease-modifying-drug-use-a-multinational-cohort-study-explained
DONATE: The Mendoza Family Fund (in Partnership with the National MS Society)
https://nationalmssociety.org/how-you-can-help/ways-to-give/mendoza
LEARN MORE: ChatGPT For Clinicians
https://chatgpt.com/plans/clinicians
AbleNOW
https://ablenow.com
JOIN: The RealTalk MS Facebook Group
https://facebook.com/groups/realtalkms
REVIEW: Give RealTalk MS a rating and review
http://www.realtalkms.com/review
Follow RealTalk MS on X, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.
RealTalk MS Episode 452
Guest: Dr. Larry Sherman


