- February 28 Bonus Episode: ACTRIMS 2021
- February 16 Episode 181: Sex and MS with Dr. Linda Mona
- November 24 Episode 169: MSTranslate with Brett Drummond
- September 18 Bonus: The MSVirtual2020 Conference
- September 15 Episode 159: Resilience and MS with Dr. Dawn Ehde
- March 1 Bonus Episode: ACTRIMS 2020
- February 11 Episode 128: Pregnancy & MS with Dr. Riley Bove
- January 14 Episode 124: First Descents with Brad Ludden
- September 14 Bonus Episode: ECTRIMS 2019 Day Three
- September 13 Bonus Episode: ECTRIMS 2019 Day Two
- September 11 Bonus Episode: ECTRIMS 2019 Day 1
- August 20 Episode 103: Kyra Millich's MS Journey
- December 31 Episode 71: Our Look Back at 2018
- October 16 Episode 60: ECTRIMS Wrap-Up
- October 16 Episode 60: ECTRIMS Wrap-Up
- October 13 Episode 59: Live from Day 3 of ECTRIMS 2018
- October 12 Episode 58: Live from Day 2 of ECTRIMS 2018
- October 11 Episode 57: Live from Day 1 at ECTRIMS 2018
- October 9 Episode 56: On the Road to ECTRIMS
- July 17 Gender Differences & MS
- July 10 Episode 43: Cannabis & MS
- January 16 RealTalk MS Episode 15: We Are Illmatic
- November 28 RealTalk MS Episode 11: News Roundup
- November 21 RealTalk MS Episode 10: Caregiving
- November 14 RealTalk MS Episode 9: MS & Depression
- November 7 RealTalk MS Episode 8: The MS MOSAIC Study
- October 31 RealTalk MS Episode 7: ECTRIMS Round-Up
- October 10 RealTalk MS Episode 4: Progressive MS
- September 23 RealTalk MS Episode 1: Introducing RealTalk MS