Past Podcast Episodes

Back in Episode #401, we reported promising results from a Phase 2 clinical trial for vidofludimus calcium and its impact on progressive MS. This therapy is being developed by Immunic Therapeutics, and this week, Jason Tardio, Immunic's President and Chief Operating Officer, joins me to share some of the specifics of that clinical trial.

Jason will also shed light on why Immunic believes that vidofludimus calcium goes beyond merely slowing disability, potentially offering vital neuroprotection for MS patients, making it a potential game-changer.

We're also sharing the encouraging results from a study that focused on the efficacy of neural stem cell transplantation as a remyelination therapy.

We'll tell you about a study in the U.K. that measured disability progression among people with MS five years after undergoing autologous hematopoietic stem cell transplantation (aHSCT).

You'll learn about an AI tool that can predict whether someone living with MS is likely to experience progression independent of relapse activity (PIRA) with a high degree of accuracy.

We'll tell you where you can catch the International Progressive MS Alliance webcast featuring a panel of experts discussing the future role of digital tools in MS research.

We'll explain how one of the less publicized aspects of the One Big Beautiful Bill Act will impact future MS care.

And Crush MS is less than two weeks away! We're sharing all the details!

We have a lot to talk about! Are you ready for RealTalk MS??!

This Week: Encouraging results from a clinical trial for progressive MS. :22

How a less-publicized aspect of the One Big Beautiful Bill Act will impact future MS patient care 1:18

A study looked at the efficacy of neural stem cell transplantation as a remyelination therapy 4:31

A study in the U.K. analyzed disability progression among people with MS five years after receiving autologous hematopoietic stem cell therapy (aHSCT) 7:42

Can AI accurately predict who will experience progression independent of relapse activity (PIRA)? 10:45

Don't miss the International Progressive MS Alliance webcast featuring experts discussing the future role of digital tools in MS research 12:40

Are you ready to support MS research while spending the afternoon in a Napa Valley vineyard? Get all the details to attend Crush MS 13:45

Jason Tardio, President and Chief Operating Officer of Immunic Therapeutics, discusses the recent Phase 2 clinical trial for vidofludimus calcium as a therapy for progressive MS 15:03

Share this episode 30:03

Have you downloaded the free RealTalk MS app? 30:23

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LINKS

If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

Become an MS Activist
https://nationalmssociety.org/advocacy

STUDY: Remyelination of Chronic Demyelinated Lesions With Directly Induced Neural Stem Cells
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awaf208/8185601

STUDY: Autologous Haemotopoietic Stem Cell Transplantation in the U.K.: A 20-Year Retrospective Analysis of Activity Haematological Outcomes from the British Society of Blood And Marrow Transplantation and Cellular Therapy
https://onlinelibrary.wiley.com/doi/epdf/10.1111/bjh.20199

STUDY: Deep Learning to Predict Progression Independent of Relapse Activity at a First Demyelinating Event
https://academic.oup.com/braincomms/article/7/4/fcaf243/8185588

WEBCAST: A Discussion From the International Progressive MS Alliance's Digital Tools Workshop
https://msif.org/news/2025/07/08/webcast-digital-tools

EVENT: Crush MS
https://crushms.org

Join the RealTalk MS Facebook Group
https://facebook.com/groups/realtalkms

Download the RealTalk MS App for iOS Devices
https://itunes.apple.com/us/app/realtalk-ms/id1436917200

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RealTalk MS Episode 411
Guest: Jason Tardio

Privacy Policy

Over the past few months, we've shared news about an algorithm that can accurately predict whether someone living with MS will experience worsening symptoms or a relapse in the weeks ahead.

You've heard about a three-quarter-of-a-million-dollar investment by the International Progressive MS Alliance to support the development of an AI-based tool that will predict future disability as well as how someone with MS will respond to different disease-modifying therapies.

PMSA Digital Tools Workshop

Just last week, you learned about a digital tool that can accurately diagnose whether someone has relapsing-remitting MS or progressive MS — after a five-minute test!

Digital tools are poised to rewrite the rules when it comes to conducting MS research and providing patient care. Welcome to Part Two of our coverage of the Digital Tools Workshop hosted by the International Progressive MS Alliance.

In this week's episode, you'll hear Vanessa Fanning share her perspective as someone living with progressive MS on how digital tools can benefit people with progressive MS, while also highlighting some of the challenges that need to be addressed.

Then, you'll hear neuroimmunologist and data scientist Professor Sergio Baranzini discuss how all the data that digital tools produce will be integrated into MS research and MS care.

Dr. Ruth Ann Marrie recaps the topics covered at the meeting and describes the next steps necessary to integrate digital tools into MS clinical care.

And we'll have to take a moment to share the frightening real-world consequences of last week's decision by President Trump and Congress to cut a trillion dollars from Medicaid.

We have a lot to talk about! Are you ready for RealTalk MS??!

This Week: The real-world impact of the Big Beautiful Bill on people with MS and any other chronic illness :22

An example of how a digital tool could revolutionize MS patient care 7:41

Vanessa Fanning shares a patient's perspective on how digital tools can benefit people living with progressive MS and reminds us of the challenges that still need to be solved 11:19

Professor Sergio Baranzini discusses managing big data in the clinic 23:15

Dr. Ruth Ann Marrie provides a recap of the workshop and describes the next steps to be taken 31:07

Share this episode 43:21

Have you downloaded the free RealTalk MS app? 43:41